HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation

• Main Authors: Daniele Mancardi (Author), Pasquale Pagliaro (Author), Lisa A. Ridnour (Author), Carlo G. Tocchetti (Author), Katrina Miranda (Author), Magdalena Juhaszova (Author), Steven J. Sollott (Author), David A. Wink (Author), Nazareno Paolocci (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Donors of nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO^.), positively modulate cardiac contractility/relaxation while limiting ischemia-reperfusion (I/R) injury. The mechanisms underpinning HNO anti-ischemic effects remain poorly understood. Using isol...