Size Matters: Arginine-Derived Peptides Targeting the PSMA Receptor Can Efficiently Complex but Not Transfect siRNA

• Main Authors: Christopher N. Cultrara (Author), Sunil Shah (Author), Gina Antuono (Author), Claudia J. Heller (Author), Jorge A. Ramos (Author), Uri Samuni (Author), Jenny Zilberberg (Author), David Sabatino (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oligoarginine sequences conjugated to a short cancer-targeting peptide (CTP) selective for the prostate-specific membrane antigen (PSMA) receptor was developed for selective small interfering RNA (siRNA) delivery to a human metastatic/castration-resistant prostate cancer (PCa) cell line, which expre...