Six Highly Conserved Targets of RNAi Revealed in HIV-1-Infected Patients from Russia Are Also Present in Many HIV-1 Strains Worldwide

• Main Authors: Olga V. Kretova (Author), Daria M. Fedoseeva (Author), Maria A. Gorbacheva (Author), Natalya M. Gashnikova (Author), Maria P. Gashnikova (Author), Nataliya V. Melnikova (Author), Vladimir R. Chechetkin (Author), Yuri V. Kravatsky (Author), Nickolai A. Tchurikov (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNAi has been suggested for use in gene therapy of HIV/AIDS, but the main problem is that HIV-1 is highly variable and could escape attack from the small interfering RNAs (siRNAs) due to even single nucleotide substitutions in the potential targets. To exhaustively check the variability in selected...