N,N-Dimethylacetamide Significantly Attenuates LPS- and TNFα-Induced Proinflammatory Responses Via Inhibition of the Nuclear Factor Kappa B Pathway

• Main Authors: Ryan Pekson (Author), Vladimir Poltoratsky (Author), Samir Gorasiya (Author), Sruthi Sundaram (Author), Charles R. Ashby (Author), Ivana Vancurova (Author), Sandra E. Reznik (Author)
• Format: Book
• Published: BMC, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Previously, we have shown that N,N-dimethylacetamide (DMA) prevents inflammation-induced preterm birth in a murine model, inhibits lipopolysaccharide (LPS)-induced increases in placental proinflammatory cytokines and upregulates the antiinflammatory cytokine interleukin-10 (IL-10). However,...