An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages

• Autores principales: Vanessa Moreira (Autor), Bruno Lomonte (Autor), Marco Aurélio Ramirez Vinolo (Autor), Rui Curi (Autor), José María Gutiérrez (Autor), Catarina Teixeira (Autor)
• Formato: Libro
• Publicado: Hindawi Limited, 2014-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Phospholipases A2 (PLA2) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2). Herein, we explored the molecular mechanisms...