An Asp49 Phospholipase A2 from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2 Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages

Phospholipases A2 (PLA2) are key enzymes for production of lipid mediators. We previously demonstrated that a snake venom sPLA2 named MT-III leads to prostaglandin (PG)E2 biosynthesis in macrophages by inducing the expression of cyclooxygenase-2 (COX-2). Herein, we explored the molecular mechanisms...

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Bibliographic Details
Main Authors: Vanessa Moreira (Author), Bruno Lomonte (Author), Marco Aurélio Ramirez Vinolo (Author), Rui Curi (Author), José María Gutiérrez (Author), Catarina Teixeira (Author)
Format: Book
Published: Hindawi Limited, 2014-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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