Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion

• Main Authors: Brandon L. Panaro (Author), Bernardo Yusta (Author), Dianne Matthews (Author), Jacqueline A. Koehler (Author), Youngmi Song (Author), Darleen A. Sandoval (Author), Daniel J. Drucker (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon-like peptide-1 is a nutrient-sensitive hormone secreted from enteroendocrine L cells within the small and large bowel. Although GLP-1 levels rise rapidly in response to food ingestion, the greatest density of L cells is localized to the distal small bowel and colon. Here, we asse...