A mouse model of brittle cornea syndrome caused by mutation in Zfp469

• Main Authors: Chloe M. Stanton (Author), Amy S. Findlay (Author), Camilla Drake (Author), Mohammad Z. Mustafa (Author), Philippe Gautier (Author), Lisa McKie (Author), Ian J. Jackson (Author), Veronique Vitart (Author)
• Format: Book
• Published: The Company of Biologists, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brittle cornea syndrome (BCS) is a rare recessive condition characterised by extreme thinning of the cornea and sclera. BCS results from loss-of-function mutations in the poorly understood genes ZNF469 or PRDM5. In order to determine the function of ZNF469 and to elucidate pathogenic mechanisms, we...