Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma

• Main Authors: Yanhong Zhang (Author), Rosalia Rabinovsky (Author), Zhiyun Wei (Author), Rachid El Fatimy (Author), Evgeny Deforzh (Author), Bai Luan (Author), Leonid Peshkin (Author), Erik J. Uhlmann (Author), Anna M. Krichevsky (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNA-10b (miR-10b) is an essential glioma driver and one of the top candidates for targeted therapies for glioblastoma and other cancers. This unique miRNA controls glioma cell cycle and viability via an array of established conventional and unconventional mechanisms. Previously reported CRISPR-...