Mass balance and pharmacokinetics of an oral dose of 14C‐napabucasin in healthy adult male subjects

• Main Authors: Xiaoshu Dai (Author), Michael D. Karol (Author), Matthew Hitron (Author), Marjie L. Hard (Author), John Evan Blanchard (Author), Nicola C. J. E. Eraut (Author), Natalie Rich (Author), Brandon T. Gufford (Author)
• Format: Knjiga
• Izdano: Wiley, 2021-02-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract This phase 1, open‐label study assessed14C‐napabucasin absorption, metabolism, and excretion, napabucasin pharmacokinetics, and napabucasin metabolites (primary objectives); safety/tolerability were also evaluated. Eight healthy males (18-45 years) received a single oral 240‐mg napabucasin...