Developmental changes and metabolic reprogramming during establishment of infection and progression of Trypanosoma brucei brucei through its insect host.

• Main Authors: Arunasalam Naguleswaran (Author), Paula Fernandes (Author), Shubha Bevkal (Author), Ruth Rehmann (Author), Pamela Nicholson (Author), Isabel Roditi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma brucei ssp., unicellular parasites causing human and animal trypanosomiasis, are transmitted between mammals by tsetse flies. Periodic changes in variant surface glycoproteins (VSG), which form the parasite coat in the mammal, allow them to evade the host immune response. Different isola...