Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

• Prif Awduron: Victor Sebastian-Perez (Awdur), Alfonso García-Rubia (Awdur), Sayed H. Seif el-Din (Awdur), Abdel-Nasser A. Sabra (Awdur), Naglaa M. El-Lakkany (Awdur), Samia William (Awdur), Tom L. Blundell (Awdur), Louis Maes (Awdur), Ana Martinez (Awdur), Nuria E. Campillo (Awdur), Sanaa S. Botros (Awdur), Carmen Gil (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here. The in vivo studies in a S. mansoni mouse model show...