Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

• Main Authors: Victor Sebastian-Perez (Author), Alfonso García-Rubia (Author), Sayed H. Seif el-Din (Author), Abdel-Nasser A. Sabra (Author), Naglaa M. El-Lakkany (Author), Samia William (Author), Tom L. Blundell (Author), Louis Maes (Author), Ana Martinez (Author), Nuria E. Campillo (Author), Sanaa S. Botros (Author), Carmen Gil (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here. The in vivo studies in a S. mansoni mouse model show...