Discovery and SAR analysis of 5-chloro-4-((substituted phenyl)amino)pyrimidine bearing histone deacetylase inhibitors

Histone deacetylases (HDACs) are validated targets for the development of anticancer drugs in epigenetics. In the discovery of novel HDAC inhibitors with anticancer potency, the 5-chloro-4-((substituted phenyl)amino)pyrimidine fragment is assembled as a cap group into the structure of HDAC inhibitor...

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Main Authors: Lin Zhang (Author), Yiming Chen (Author), Fahui Li (Author), Lihui Zhang (Author), Jinhong Feng (Author), Lei Zhang (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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