A novel approach to identify the mechanism of miR-145-5p toxicity to podocytes based on the essential genes targeting analysis

• मुख्य लेखकों: Sipan Zhang (लेखक), Junnan Wu (लेखक), Xiaodong Zhu (लेखक), Hui Song (लेखक), Lu Ren (लेखक), Qiaoli Tang (लेखक), Xiaodong Xu (लेखक), Chunbei Liu (लेखक), Jiong Zhang (लेखक), Weixin Hu (लेखक), Zhihong Liu (लेखक), Shaolin Shi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

MicroRNAs (miRNAs) are emerging as effective therapeutic agents. When testing whether miR-145-5p could alleviate kidney injury, we unexpectedly found that extracellular vesicles loaded with miR-145-5p induced proteinuria and podocyte foot process effacement in normal control mice. To explore the mec...