A novel approach to identify the mechanism of miR-145-5p toxicity to podocytes based on the essential genes targeting analysis

• Main Authors: Sipan Zhang (Author), Junnan Wu (Author), Xiaodong Zhu (Author), Hui Song (Author), Lu Ren (Author), Qiaoli Tang (Author), Xiaodong Xu (Author), Chunbei Liu (Author), Jiong Zhang (Author), Weixin Hu (Author), Zhihong Liu (Author), Shaolin Shi (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNAs (miRNAs) are emerging as effective therapeutic agents. When testing whether miR-145-5p could alleviate kidney injury, we unexpectedly found that extracellular vesicles loaded with miR-145-5p induced proteinuria and podocyte foot process effacement in normal control mice. To explore the mec...