Histamine promotes angiogenesis through a histamine H1 receptor-PKC-VEGF-mediated pathway in human endothelial cells

• Main Authors: Omer Faruk Hatipoglu (Author), Takashi Nishinaka (Author), Masahiro Nishibori (Author), Masahiro Watanabe (Author), Takao Toyomura (Author), Shuji Mori (Author), Kursat Oguz Yaykasli (Author), Hidenori Wake (Author), Hideo Takahashi (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histamine is a well-known inflammatory mediator, but how histamine induces angiogenesis remains poorly understood. In the present study, we demonstrated a dose-dependent dynamic tube formation in the human endothelial cell line EA.hy926 in the presence of histamine that was completely blocked by his...