Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP

• Main Authors: Oskar Gustafsson (Author), Julia Rädler (Author), Samantha Roudi (Author), Tõnis Lehto (Author), Mattias Hällbrink (Author), Taavi Lehto (Author), Dhanu Gupta (Author), Samir EL Andaloussi (Author), Joel Z. Nordin (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The toolbox for genetic engineering has quickly evolved from CRISPR/Cas9 to a myriad of different gene editors, each with promising properties and enormous clinical potential. However, a major challenge remains: delivering the CRISPR machinery to the nucleus of recipient cells in a nontoxic and effi...