A Randomized, Open-Label, Phase I, Single-Dose Study of Antisense Oligonucleotide, Vupanorsen, in Chinese Adults with Elevated Triglycerides

Abstract Background Vupanorsen is a GalNAc3-conjugated antisense oligonucleotide targeting angiopoietin-like 3 (ANGPTL3) mRNA shown to reduce atherogenic lipoproteins in individuals with dyslipidemia. Objectives The aim of this study was to satisfy Chinese regulatory requirements and support ethnic...

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主要な著者: Xiaojie Wu (著者), Jicheng Yu (著者), Beikang Ge (著者), Jeffrey Wang (著者), Xiaoran Han (著者), Chunye Zhang (著者), Xiaomeng Mao (著者), Hindu Kalluru (著者), Candace Bramson (著者), Steven G. Terra (著者), Jing Liu (著者)
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出版事項: Adis, Springer Healthcare, 2024-07-01T00:00:00Z.
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