The neurosteroid allopregnanolone sulfate inhibits Nav1.3 α subunit-containing voltage-gated sodium channels, expressed in Xenopus oocytes

• Prif Awduron: Takafumi Horishita (Awdur), Nobuyuki Yanagihara (Awdur), Susumu Ueno (Awdur), Dan Okura (Awdur), Reiko Horishita (Awdur), Tomoko Minami (Awdur), Yuichi Ogata (Awdur), Yuka Sudo (Awdur), Yasuhito Uezono (Awdur), Takashi Kawasaki (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2018-05-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The neurosteroid allopregnanolone has potent analgesic effects, and its potential use for neuropathic pain is supported by recent reports. However, the analgesic mechanisms are obscure. The voltage-gated sodium channels (Nav) α subunit Nav1.3 is thought to play an essential role in neuropathic pain....