Application of a pharmacokinetic model of metformin clearance in a population with acute myeloid leukemia

• Main Authors: Alice C Ceacareanu (Author), Geoffrey W Brown (Author), Hoda A Moussa (Author), Zachary A P. Wintrob (Author)
• Formato: Livro
• Publicado em: Wolters Kluwer Medknow Publications, 2018-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: We aimed to estimate the metformin-associated lactic acidosis (MALA) risk by assessing retrospectively the renal clearance variability and applying a pharmacokinetic (PK) model of metformin clearance in a population diagnosed with acute myeloid leukemia (AML) and diabetes mellitus (DM). M...