The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy.

• Main Authors: Juliana Elena Silveira Pratti (Author), Alessandra Marcia da Fonseca Martins (Author), Juliana Paiva da Silva (Author), Tadeu Diniz Ramos (Author), Joyce Carvalho Pereira (Author), Luan Firmino-Cruz (Author), Diogo Oliveira-Maciel (Author), Thiago Soares de Souza Vieira (Author), Leandra Linhares Lacerda (Author), Andre Macedo Vale (Author), Celio G Freire- (Author), Daniel C Oliveira Gomes (Author), Elvira M Saraiva (Author), Bartira Rossi-Bergmann (Author), Herbert Leonel de Matos Guedes (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2019-02-01T00:00:00Z.
• Fag: article
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Leishmania (L.) amazonensis is one of the etiological agents of cutaneous leishmaniasis (CL) in Brazil. Currently, there is no vaccine approved for human use against leishmaniasis, although several vaccine preparations are in experimental stages. One of them is Leishvacin, or LaAg, a first-generatio...