Gut Microbiota-Mediated Transformation of Coptisine Into a Novel Metabolite 8-Oxocoptisine: Insight Into Its Superior Anti-Colitis Effect

• Main Authors: Gaoxiang Ai (Author), Ziwei Huang (Author), Juanjuan Cheng (Author), Jianhui Xie (Author), Huifang Zeng (Author), Yuhong Liu (Author), Yucui Li (Author), Xiaoqi Huang (Author), Jiannan Chen (Author), Ziren Su (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coptisine (COP) is a bioactive isoquinoline alkaloid derived from Coptis Chinemsis Franch, which is traditionally applied for the management of colitis. However, the blood concentration of COP was extremely low, and its gut microbiota-mediated metabolites were thought to contribute to its prominent...