Modification and Structure-Activity Relationship Study of Cyclodepsipeptide Trichodestruxin D Derivatives as Potential Antitumor Agents

• Main Authors: Jihua Zou (Author), Yifei Lu (Author), Xiang Li (Author), Conghao Gai (Author), Yan Zou (Author), Qingjie Zhao (Author)
• Format: Book
• Published: Georg Thieme Verlag KG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trichodestruxins A-D are cyclic peptides isolated from the plant endophyte fungus Trichoderma harzianum with inhibitory activities against the proliferation of tumor cells. This study aimed to modify the structure of trichodestruxin D (TD-(R)) to improve its antitumor activity and analyze the struct...