Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia

• Egile Nagusiak: Alastair G Kerr (Egilea), Lawrence CS Tam (Egilea), Ashley B Hale (Egilea), Milena Cioroch (Egilea), Gillian Douglas (Egilea), Keith M Channon (Egilea), Richard Wade-Martins (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2016-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Familial hypercholesterolemia (FH) is a life-threatening genetic disorder characterized by elevated levels of plasma low-density lipoprotein cholesterol (LDL-cholesterol). Current attempts at gene therapy for FH have been limited by the use of strong heterologous promoters which lack genomic DNA ele...