Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia

• Prif Awduron: Alastair G Kerr (Awdur), Lawrence CS Tam (Awdur), Ashley B Hale (Awdur), Milena Cioroch (Awdur), Gillian Douglas (Awdur), Keith M Channon (Awdur), Richard Wade-Martins (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2016-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Familial hypercholesterolemia (FH) is a life-threatening genetic disorder characterized by elevated levels of plasma low-density lipoprotein cholesterol (LDL-cholesterol). Current attempts at gene therapy for FH have been limited by the use of strong heterologous promoters which lack genomic DNA ele...