Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via β-Klotho and perilipin 2

• Main Authors: Yonat Tzur (Author), Katarzyna Winek (Author), Nimrod Madrer (Author), Serafima Dubnov (Author), Estelle R. Bennett (Author), David S. Greenberg (Author), Geula Hanin (Author), Asaad Gammal (Author), Joseph Tam (Author), Isaiah T. Arkin (Author), Iddo Paldor (Author), Hermona Soreq (Author)
• Formato: Libro
• Publicado: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Objective: Non-alcoholic fatty liver disease (NAFLD) involves hepatic accumulation of intracellular lipid droplets via incompletely understood processes. Here, we report distinct and cooperative NAFLD roles of LysTTT-5'tRF transfer RNA fragments and microRNA miR-194-5p. Methods: Combined use of...