CD226 Is Required to Maintain Megakaryocytes/Platelets Homeostasis in the Treatment of Knee Osteoarthritis With Platelet-Rich Plasma in Mice

• Main Authors: Yongming Liu (Author), Yuan Zhang (Author), Jinxue Zhang (Author), Jingchang Ma (Author), Ka Bian (Author), Yuling Wang (Author), Xuexue Xu (Author), Shuwen Wu (Author), Kun Cheng (Author), Yun Zhang (Author), Yong Ding (Author), Yong Zhou (Author), Ran Zhuang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Platelet-rich plasma (PRP) is a platelet-based application used to treat osteoarthritis (OA) clinically. The co-stimulatory molecule CD226 is expressed in T cells, NK cells, and also platelets. However, exact effects of CD226 on platelets and whether its expression level influences PRP efficacy are...