Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease

Purpose. Neutrophil-dominated airway inflammation is a key feature of progressive lung damage in cystic fibrosis (CF). Thus, reducing airway inflammation is a major goal to prevent lung damage in CF. However, current anti-inflammatory drugs have shown several limits. PI3Kγ plays a pivotal role in le...

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Hoofdauteurs: Maria Galluzzo (Auteur), Elisa Ciraolo (Auteur), Monica Lucattelli (Auteur), Eriola Hoxha (Auteur), Martina Ulrich (Auteur), Carlo Cosimo Campa (Auteur), Giuseppe Lungarella (Auteur), Gerd Doring (Auteur), Zhe Zhou-Suckow (Auteur), Marcus Mall (Auteur), Emilio Hirsch (Auteur), Virginia De Rose (Auteur)
Formaat: Boek
Gepubliceerd in: Hindawi Limited, 2015-01-01T00:00:00Z.
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