Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease

• Main Authors: Maria Galluzzo (Author), Elisa Ciraolo (Author), Monica Lucattelli (Author), Eriola Hoxha (Author), Martina Ulrich (Author), Carlo Cosimo Campa (Author), Giuseppe Lungarella (Author), Gerd Doring (Author), Zhe Zhou-Suckow (Author), Marcus Mall (Author), Emilio Hirsch (Author), Virginia De Rose (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Neutrophil-dominated airway inflammation is a key feature of progressive lung damage in cystic fibrosis (CF). Thus, reducing airway inflammation is a major goal to prevent lung damage in CF. However, current anti-inflammatory drugs have shown several limits. PI3Kγ plays a pivotal role in le...