Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease

• Auteurs principaux: Maria Galluzzo (Auteur), Elisa Ciraolo (Auteur), Monica Lucattelli (Auteur), Eriola Hoxha (Auteur), Martina Ulrich (Auteur), Carlo Cosimo Campa (Auteur), Giuseppe Lungarella (Auteur), Gerd Doring (Auteur), Zhe Zhou-Suckow (Auteur), Marcus Mall (Auteur), Emilio Hirsch (Auteur), Virginia De Rose (Auteur)
• Format: Livre
• Publié: Hindawi Limited, 2015-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Purpose. Neutrophil-dominated airway inflammation is a key feature of progressive lung damage in cystic fibrosis (CF). Thus, reducing airway inflammation is a major goal to prevent lung damage in CF. However, current anti-inflammatory drugs have shown several limits. PI3Kγ plays a pivotal role in le...