Surface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo pharmacokinetic assessment

• Main Authors: Hibah M. Aldawsari (Author), Shaimaa M. Badr-Eldin (Author), Nourah Y. Assiri (Author), Nabil A. Alhakamy (Author), Anna Privitera (Author), Filippo Caraci (Author), Giuseppe Caruso (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vinpocetine (VNP), a semisynthetic active pharmaceutical ingredient, is used for oral management of cerebrovascular diseases because of its ability to enhance the blood flow to the brain. However, despite that, the therapeutic application of VNP is restricted due to its reduced bioavailability and d...