Molecular evidence for a functional ecdysone signaling system in Brugia malayi.

• Main Authors: George Tzertzinis (Author), Ana L Egaña (Author), Subba Reddy Palli (Author), Marc Robinson-Rechavi (Author), Chris R Gissendanner (Author), Canhui Liu (Author), Thomas R Unnasch (Author), Claude V Maina (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles. An understanding of how these parasites cross developmental checkpoints may reveal potential targets for intervent...