Protective Effect of Buckwheat Polyphenols Against Long-Lasting Impairment of Spatial Memory Associated With Hippocampal Neuronal Damage in Rats Subjected to Repeated Cerebral Ischemia

• Main Authors: Fengling Pu (Author), Kenichi Mishima (Author), Nobuaki Egashira (Author), Katsunori Iwasaki (Author), Tomohiro Kaneko (Author), Tomoko Uchida (Author), Keiichi Irie (Author), Daisuke Ishibashi (Author), Hajime Fujii (Author), Kenichi Kosuna (Author), Michihiro Fujiwara (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present experiment, we studied the action of buckwheat polyphenol (BWP, from Fagopyrum esculentum MOENCH) in a repeated cerebral ischemia model, which induced a strong and long-lasting impairment of spatial memory in 8-arm radial maze with hippocampal CA1 cell death in rats. BWP (600 mg/kg, c...