The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia

• Main Authors: Robin Michelet (Author), Moreno Ursino (Author), Sandrine Boulet (Author), Sebastian Franck (Author), Fiordiligie Casilag (Author), Mara Baldry (Author), Jens Rolff (Author), Madelé van Dyk (Author), Sebastian G. Wicha (Author), Jean-Claude Sirard (Author), Emmanuelle Comets (Author), Sarah Zohar (Author), Charlotte Kloft (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2021-04-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The treatment of respiratory tract infections is threatened by the emergence of bacterial resistance. Immunomodulatory drugs, which enhance airway innate immune defenses, may improve therapeutic outcome. In this concept paper, we aim to highlight the utility of pharmacometrics and Bayesian inference...