Xanthine Derivative KMUP-1 Attenuates Experimental Periodontitis by Reducing Osteoclast Differentiation and Inflammation

• Main Authors: Cheng-Hsiang Kuo (Author), Ban-Hua Zhang (Author), Shang-En Huang (Author), Jong-Hau Hsu (Author), Yan-Hsiung Wang (Author), Thi Tuyet Ngan Nguyen (Author), Chao-Han Lai (Author), Jwu-Lai Yeh (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Periodontitis is an inflammatory disease of gum that may predispose to serious systemic complications such as diabetes and cardiovascular diseases. Activation of macrophages and osteoclasts around periodontal tissue can accelerate gum inflammation. In addition, alteration of cyclic nucleotide levels...