Controlled Delivery of BET-PROTACs: In Vitro Evaluation of MZ1-Loaded Polymeric Antibody Conjugated Nanoparticles in Breast Cancer

• Main Authors: Francisco J. Cimas (Author), Enrique Niza (Author), Alberto Juan (Author), María del Mar Noblejas-López (Author), Iván Bravo (Author), Agustín Lara-Sanchez (Author), Carlos Alonso-Moreno (Author), Alberto Ocaña (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bromo and extraterminal domain (BET) inhibitors-PROteolysis TArgeting Chimera (BETi-PROTAC) is a new family of compounds that induce proteasomal degradation through the ubiquitination of the tagged to BET inhibitors Bromodomain proteins, BRD2 and BRD. The encapsulation and controlled release of BET-...