Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery

• Main Authors: Frédéric Tewes (Author), Julien Brillault (Author), Nicolas Gregoire (Author), Jean-Christophe Olivier (Author), Isabelle Lamarche (Author), Christophe Adier (Author), Anne-Marie Healy (Author), Sandrine Marchand (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To assess the difference in the fate of the antibiotic colistin (COLI) after its pulmonary delivery as a powder or a solution, we developed a COLI powder and evaluated the COLI pharmacokinetic properties in rats after pulmonary administration of the powder or the solution. The amorphous COLI powder...