Variable Responses to CFTR Correctors in vitro: Estimating the Design Effect in Precision Medicine

• Main Authors: Elizabeth Matthes (Author), Julie Goepp (Author), Carolina Martini (Author), Jiajie Shan (Author), Jie Liao (Author), David Y. Thomas (Author), John W. Hanrahan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interest in precision medicine has grown in recent years due to the variable clinical benefit provided by some medications, their cost, and by new opportunities to tailor therapies to individual patients. In cystic fibrosis it may soon be possible to test several corrector drugs that improve the fol...