Fenofibrate Decreases Hepatic P-Glycoprotein in a Rat Model of Hereditary Hypertriglyceridemia

• Main Authors: Martin Poruba (Author), Zuzana Matuskova (Author), Martina Hüttl (Author), Hana Malinska (Author), Olena Oliyarnyk (Author), Irena Markova (Author), Sona Gurska (Author), Ludmila Kazdova (Author), Rostislav Vecera (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (P-gp) is a membrane-bound transporter encoded by Mdr1a/Abcb1a and Mdr1b/Abcb1b genes in rodents involved in the efflux of cytotoxic chemicals and metabolites from cells. Modulation of its activity influences P-gp-mediated drug delivery and drug-drug interaction (DDI). In the current...