Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal

• Main Authors: Xiaofen Huang (Author), Yike Li (Author), Meifeng Nie (Author), Mingxi Yue (Author), Yufang Li (Author), Zhijie Lin (Author), Huirong Pan (Author), Mujin Fang (Author), Ting Wu (Author), Shaowei Li (Author), Jun Zhang (Author), Ningshao Xia (Author), Qinjian Zhao (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thimerosal has been widely used as a preservative in drug and vaccine products for decades. Due to the strong propensity to modify thiols in proteins, conformational changes could occur due to covalent bond formation between ethylmercury (a degradant of thimerosal) and thiols. Such a conformational...