Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model

• Main Authors: Valentina Latina (Author), Margherita De Introna (Author), Chiara Caligiuri (Author), Alessia Loviglio (Author), Rita Florio (Author), Federico La Regina (Author), Annabella Pignataro (Author), Martine Ammassari-Teule (Author), Pietro Calissano (Author), Giuseppina Amadoro (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tau-targeted immunotherapy is a promising approach for treatment of Alzheimer's disease (AD). Beyond cognitive decline, AD features visual deficits consistent with the manifestation of Amyloid β-protein (Aβ) plaques and neurofibrillary tangles (NFT) in the eyes and higher visual centers, both i...