Central nervous system manifestations of LRBA deficiency: case report of two siblings and literature review

• Main Authors: T. C. Mangodt (Author), K. Vanden Driessche (Author), K. K. Norga (Author), N. Moes (Author), M. De Bruyne (Author), F. Haerynck (Author), V. Bordon (Author), A. C. Jansen (Author), A. I. Jonckheere (Author)
• Format: Book
• Published: BMC, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency disease (PID) characterized by a regulatory T cell defect resulting in immune dysregulation and autoimmunity. We present two siblings born to consanguineous parents of North African descent w...