CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants

• Main Authors: Lingxin Zhang (Author), Vivekananda Sarangi (Author), Irene Moon (Author), Jia Yu (Author), Duan Liu (Author), Sandhya Devarajan (Author), Joel M. Reid (Author), Krishna R. Kalari (Author), Liewei Wang (Author), Richard Weinshilboum (Author)
• Format: Book
• Published: Wiley, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Single nucleotide variants in the open reading frames (ORFs) of pharmacogenes are important causes of interindividual variability in drug response. The functional characterization of variants of unknown significance within ORFs remains a major challenge for pharmacogenomics. Deep mutational scanning...