Gut microbiota-brain bile acid axis orchestrates aging-related neuroinflammation and behavior impairment in mice

• Main Authors: Junli Ma (Author), Mingxiao Li (Author), Yiyang Bao (Author), Wenjin Huang (Author), Xiaofang He (Author), Ying Hong (Author), Wenjing Wei (Author), Zekun Liu (Author), Xinxin Gao (Author), Yang Yang (Author), Zhengyu Cui (Author), Wantao Wang (Author), Jie Wang (Author), Weize Zhu (Author), Ningning Zheng (Author), Lingyun Pan (Author), Deheng Wang (Author), Zunji Ke (Author), Ben Zhou (Author), Lili Sheng (Author), Houkai Li (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Emerging evidence shows that disrupted gut microbiota-bile acid (BA) axis is critically involved in the development of neurodegenerative diseases. However, the alterations in spatial distribution of BAs among different brain regions that command important functions during aging and their exact roles...