Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia

• Main Authors: Patricia P. Jumbo-Lucioni (Author), Marquise L. Hopson (Author), Darwin Hang (Author), Yongliang Liang (Author), Dean P. Jones (Author), Judith L. Fridovich-Keil (Author)
• Format: Book
• Published: The Company of Biologists, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Classic galactosemia is a genetic disorder that results from profound loss of galactose-1P-uridylyltransferase (GALT). Affected infants experience a rapid escalation of potentially lethal acute symptoms following exposure to milk. Dietary restriction of galactose prevents or resolves the acu...