Inhibitory Effect of Thiopental on Ultra-rapid Delayed Rectifier K+ Current in H9c2 Cells

• Main Authors: Hideki Suzuki (Author), Nobuo Momoi (Author), Tomoyuki Ono (Author), Sachiko Maeda (Author), Yayoi Shikama (Author), Isao Matsuoka (Author), Hitoshi Suzuki (Author), Junko Kimura (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Using the whole-cell voltage clamp technique, we investigated the effects of thiopental on membrane currents in H9c2 cells, a cell line derived from embryonic rat heart. Thiopental blocked a rapidly activating, very slowly-inactivating ultra-rapid type IKur-like outward K+ current in a concentration...