Combined Treatment with Acalabrutinib and Rapamycin Inhibits Glioma Stem Cells and Promotes Vascular Normalization by Downregulating BTK/mTOR/VEGF Signaling

• Main Authors: Yu-Kai Su (Author), Oluwaseun Adebayo Bamodu (Author), I-Chang Su (Author), Narpati Wesa Pikatan (Author), Iat-Hang Fong (Author), Wei-Hwa Lee (Author), Chi-Tai Yeh (Author), Hsiao-Yean Chiu (Author), Chien-Min Lin (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with a median duration of survival of approximately 14 months after diagnosis. High resistance to chemotherapy remains a major problem. Previously, BTK has been shown to be involved in the intracellular signal transductio...