Valproic Acid Suppresses Autoimmune Recurrence and Allograft Rejection in Islet Transplantation through Induction of the Differentiation of Regulatory T Cells and Can Be Used in Cell Therapy for Type 1 Diabetes

• Main Authors: Jeng-Rong Lin (Author), Shing-Hwa Huang (Author), Chih-Hsiung Wu (Author), Yuan-Wu Chen (Author), Zhi-Jie Hong (Author), Chia-Pi Cheng (Author), Huey-Kang Sytwu (Author), Gu-Jiun Lin (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Type 1 diabetes mellitus (T1D) results from the destruction of insulin-producing β cells in the islet of the pancreas by lymphocytes. Non-obese diabetic (NOD) mouse is an animal model frequently used for this disease. It has been considered that T1D is a T cell-mediated autoimmune disease. Both CD4+...