Characterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies

• Main Authors: Goodell Cara AR (Author), Belisle Jennifer A (Author), Gubbels Jennifer AA (Author), Migneault Martine (Author), Rancourt Claudine (Author), Connor Joseph (Author), Kunnimalaiyaan Muthusamy (Author), Kravitz Rachel (Author), Tucker Ward (Author), Zwick Michael (Author), Patankar Manish S (Author)
• Format: Book
• Published: BMC, 2009-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Objectives</p> <p>The ovarian tumor marker CA125 is expressed on human MUC16, a cell surface bound mucin that is also shed by proteolytic cleavage. Human MUC16 is overexpressed by ovarian cancer cells. MUC16 facilitates the binding of ovarian tumor ce...