Paclitaxel Increases High Voltage-Dependent Calcium Channel Current in Dorsal Root Ganglion Neurons of the Rat

• Main Authors: Kazuyoshi Kawakami (Author), Terumasa Chiba (Author), Nobuyuki Katagiri (Author), Maya Saduka (Author), Kenji Abe (Author), Iku Utsunomiya (Author), Toshihiro Hama (Author), Kyoji Taguchi (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peripheral neuropathic pain is a serious side effect of paclitaxel treatment. However, the mechanism of this paclitaxel-induced neuropathic pain is unknown. In this study, we investigated the effects of paclitaxel on the voltage-dependent calcium channel (VDCC) current in rat dorsal root ganglion (D...