Phosphate-dependent FGF23 secretion is modulated by PiT2/Slc20a2

• Main Authors: Nina Bon (Author), Giulia Frangi (Author), Sophie Sourice (Author), Jérôme Guicheux (Author), Sarah Beck-Cormier (Author), Laurent Beck (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The canonical role of the bone-derived fibroblast growth factor 23 (Fgf23) is to regulate the serum inorganic phosphate (Pi) level. As part of a feedback loop, serum Pi levels control Fgf23 secretion through undefined mechanisms. We recently showed in vitro that the two high-affinity Na+-...