Phosphate-dependent FGF23 secretion is modulated by PiT2/Slc20a2

• Автори: Nina Bon (Автор), Giulia Frangi (Автор), Sophie Sourice (Автор), Jérôme Guicheux (Автор), Sarah Beck-Cormier (Автор), Laurent Beck (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2018-05-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Objective: The canonical role of the bone-derived fibroblast growth factor 23 (Fgf23) is to regulate the serum inorganic phosphate (Pi) level. As part of a feedback loop, serum Pi levels control Fgf23 secretion through undefined mechanisms. We recently showed in vitro that the two high-affinity Na+-...