Development of Tat-Conjugated Dendrimer for Transdermal DNA Vaccine Delivery

• Main Authors: Azadeh Bahadoran (Author), Hassan Moeini (Author), Mohd Hair Bejo (Author), Mohd Zobir Hussein (Author), Abdul Rahman Omar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: In order to enhance cellular uptake and to facilitate transdermal delivery of DNA vaccine, polyamidoamine (PAMAM) dendrimers conjugated with HIV transactivator of transcription (TAT) was developed. METHODS: First, the plasmid DNA (pIRES-H5/GFP) nanoparticle was formulated using PAMAM dendri...