Development of Tat-Conjugated Dendrimer for Transdermal DNA Vaccine Delivery

• Автори: Azadeh Bahadoran (Автор), Hassan Moeini (Автор), Mohd Hair Bejo (Автор), Mohd Zobir Hussein (Автор), Abdul Rahman Omar (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2016-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

PURPOSE: In order to enhance cellular uptake and to facilitate transdermal delivery of DNA vaccine, polyamidoamine (PAMAM) dendrimers conjugated with HIV transactivator of transcription (TAT) was developed. METHODS: First, the plasmid DNA (pIRES-H5/GFP) nanoparticle was formulated using PAMAM dendri...