C-C chemokine receptor-7 mediated endocytosis of antibody cargoes into intact cells

• Main Authors: Xavier eCharest-Morin (Author), Rémy ePépin (Author), Angélique eGagné-Henley (Author), Guillaume eMorissette (Author), Robert eLodge (Author), François eMarceau (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The C-C chemokine receptor-7 (CCR7) is a G protein coupled receptor that has a role in leukocyte homing, but that is also expressed in aggressive tumor cells. Preclinical research supports that CCR7 is a valid target in oncology. In view of the increasing availability of therapeutic monoclonal antib...