Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells

• Main Authors: Xiang Y. Kong (Author), Cecilie Kasi Nesset (Author), Markus Damme (Author), Else-Marit Løberg (Author), Torben Lübke (Author), Jan Mæhlen (Author), Kristin B. Andersson (Author), Petra I. Lorenzo (Author), Norbert Roos (Author), G. Hege Thoresen (Author), Arild C. Rustan (Author), Eili T. Kase (Author), Winnie Eskild (Author)
• Format: Book
• Published: The Company of Biologists, 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was later shown to be a bona fide lysosomal integral membrane protein. To gain insight into the physiological function of NCU-G1, mice with no det...