Genome-wide analysis of PDX1 target genes in human pancreatic progenitors

• Main Authors: Xianming Wang (Author), Michael Sterr (Author), Ingo Burtscher (Author), Shen Chen (Author), Anja Hieronimus (Author), Fausto Machicao (Author), Harald Staiger (Author), Hans-Ulrich Häring (Author), Gabriele Lederer (Author), Thomas Meitinger (Author), Filippo M. Cernilogar (Author), Gunnar Schotta (Author), Martin Irmler (Author), Johannes Beckers (Author), Martin Hrabě de Angelis (Author), Michael Ray (Author), Christopher V.E. Wright (Author), Mostafa Bakhti (Author), Heiko Lickert (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the function of Pdx1 is well studied in pre-clinical mod...